Exploring the relationship between eye movements and levodopa long duration response in drug-naive Parkinson's disease patients

In Parkinson's disease (PD) eye movements quantitative assessment demonstrated both saccadic and smooth pursuit movements abnormalities. Levodopa treatment exerts a reciprocally influenced Short and Long Duration Response (SDR and LDR). To date, only the effects of SDR on eye motility was investigated, reporting conflicting results. Aim of this pilot study was to investigate possible associations between eye movement parameters evaluated during SDR assessment and later achievement of a sustained LDR.