Preparation of Stable Clindamycin Phosphate Niosomes by Combination of Sorbitan Esters and their Ethoxylaed Derivatives

Purpose This study aimed to develop a niosome-encapsulated clindamycin phosphate (CMP) formulation for topical delivery. Methods The possibility of encapsulation of this antibiotic in niosomes, its stability, cytotoxicity, and antibacterial capability were evaluated. Diverse combinations of sorbitan esters and their ethoxylated derivatives with cholesterol were used to prepare the lipid vesicles. Results This series of niosomes had high physical stability depicted as unchanged size distribution curves during 6-month storage. Formulations composed of Span 60 and Tween 60 in combination with 30 mol% of cholesterol exhibited the highest encapsulation efficiency (47.14%). Minimal inhibitory concentration of the niosomal CMP against Staphylococcus aureus was higher than free CMP. Slow and biphasic release profile of CMP was also shown. Conclusions These results indicate that niosomes can be used as stable carriers for topical delivery of CMP in acne.