Characterization and phytoconstituents of Petroselinum crispum (Mill) and Coriandrum sativum (Linn) and their impacts on inflammation—An in vitro analysis against human adenocarcinoma cells with molecular docking

Petroselinum crispum (Mill) and Coriandrum sativum (Linn) are common culinary herbs enriched with a wide range of nutrients and minerals. The phytochemicals found in these plants as secondary metabolites are useful against a variety of clinical diseases such as inflammation, diabetes, and cancer. The current study used in vitro studies on adenocarcinoma human alveolar basal epithelial (A549) cells to identify the phytochemical compounds present in the petroleum ether, methanol, and aqueous extracts of P. crispum and C. sativum leaves, as well as to depict the influence of these herbs in wound healing and inflammation. In all, 1761 compounds have been found in the leaf extracts of P. crispum and C. sativum, and the identified compounds have been tested in silico against binding receptors such as CD36 and antitrypsin receptors to determine their binding affinity. The extracts had lower IC50 values on A549 cells, suggesting lower toxicity, as well as substantially faster cell migration after treatment with P. crispum and C. sativum extracts, compared to untreated cells, implying that the extracts have high anti-inflammatory activity. Among P. crispum and C. sativum extracts, the healing of the wound was faster when treated with the extracts of P. crispum.