An efficient, cyanide free total synthesis of rosuvastatin calcium
Tetrahedron(2022)
摘要
A simple, efficient, cyanide-free protocol for the total synthesis of rosuvastatin calcium was developed from inexpensive, commercially available d-arabinose; the key steps employed were Wittig reaction followed by oxa-Michael addition. The developed synthetic protocol could be adopted for industrial production of rosuvastatin calcium.
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关键词
Total synthesis,Statins,Rosuvastatin calcium,Wittig reaction,Oxa-michael addition
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