Accessing intracellular membrane transport proteins: a novel electrophysiological approach for lysosomal and mitochondrial channels and transporters

Lysosomal, mitochondrial and other internal membranes are moving into focus of transport protein research. De-orphanization of intracellular transport proteins is ongoing and pharmacological interest is rising. For example, the lysosomal leak channel TMEM175 is investigated in the context of neurodegenerative diseases, the amino acid transporter SLC15A4 is linked to inflammatory processes and mitochondrial pumps are relevant for drug safety.