Exploring the cross-talk between liver and vessels through increased morning blood pressure in hypertension

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is associated with hypertension and predicts future cardiovascular events. Purpose To compare blood pressure (BP) morning surge assessed by ambulatory blood pressure monitoring (ABPM) in hypertensive patients with and without NAFLD. Methods Sixty-five consecutive patients with newly diagnosed essential hypertension (age 57±10 years, office BP 139/87±16/9 mmHg) were studied. In all patients a routine biochemical blood examination was undertaken while BP morning surge was automatically calculated by a Spacelabs 90207 device. NAFLD was confirmed by a liver ultrasound. Accordingly, patients were divided in those with and without NAFLD (control group). Results Patients with NAFLD (n=44) in comparison with controls (n=21) had similar 24h systolic (141.6±9.9 vs 143.2±10.4 mmHg) and diastolic BP (83.6±10.23 vs 84.7±9.53 mmHg) while office BP was also not different between groups (p=NS). However, those with NAFLD were younger (55±10 vs 61±9 years, respectively, p=0.046), had higher body mass index (32.5±4.5 vs 26.3±3.8 kg/m2, p<0.001), glomerular filtration rate (93.8±17 vs 82.6±9.2 ml/min/1.73m2, p=0.013), and higher levels of morning BP surge (14.29±8.5 vs 5.92±9.01mmHg, p=0.034), compared to the non-NAFLD group. Standard deviation of BP, average real variability, coefficient of variation and dipping status were not different between groups. Conclusions At the same levels of clinic and ambulatory BP, hypertensive patients with NAFLD compared to their non-NAFLD counterparts demonstrated increased morning surge BP levels. Our finding suggests that NAFLD may demonstrate a detrimental effect to early-morning at variance to the whole-day hemodynamics. Funding Acknowledgement Type of funding sources: None.