Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

Aaron Wetten,Laura Ogle,George Mells,Vinod S Hegade,Laura Jopson,Margaret Corrigan,Jeremy Palmer,Maja Johansson,Torbjörn Bäckström,Magnus Doverskog,David E J Jones,Jessica K Dyson

HEPATOLOGY（2022）

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摘要

Elevated serum allopregnanolone is associated with severe cognitive, emotional, and itch symptoms in PBC, in keeping with its known action on GABA-A receptors. Existing novel compounds targeting allopregnanolone could offer new therapies in severely symptomatic PBC, satisfying a significant unmet need.

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关键词

primary biliary cholangitis,gaba-a receptors,potential treatment target

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