DEFECTIVE CHAPERONE-MEDIATED AUTOPHAGY IS A HALLMARK OF JOINT DAMAGE IN OSTEOARTHRITIS

I. Lorenzo-Gomez,U. Nogueira-Recalde, C. Garcia-Dominguez,N. Oreiro, J. Pinto-Tasende,M. Lotz, F. J. Blanco,B. Carames

OSTEOARTHRITIS AND CARTILAGE(2022)

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摘要
Purpose: In Osteoarthritis (OA), defects in autophagy are a hallmark of joint damage. Therefore, identifying hallmarks associated with specific autophagy subtypes could shed light to fundamental mechanisms of joint disease and facilitate the development of therapeutic strategies to prevent OA progression.
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关键词
autophagy,osteoarthritis,joint damage,chaperone-mediated
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