Versatile Approach for the Synthesis of Furo-coumarin Derivatives

Owing to useful physio-chemical properties of furo-coumarin derivatives, their synthetic and mechanistic investigation has been reported here. We have demonstrated a range of synthetic approaches to access furan-fused coumarin derivatives. Many metal mediated, base, and acid-catalyzed approaches have been revealed for the formation of this coumarin-based fused heterocycles of biological importance. In addition to this, microwave assisted synthetic routes have also been revealed. The last and most useful approach for the synthesis of these heterocycles includes the use of purely solvent as a reaction media for synthesizing these interesting classes of heterocycles.