Disinfecting activity of some diphenyltin(IV) benzoate derivative compounds
PURE AND APPLIED CHEMISTRY(2022)
摘要
Disinfecting activity test of four diphenyltin(IV) benzoate derivative compounds has been carried out. The four compounds investigated were diphenyltin (IV) di 4 aminobenzoate (DPDA) (2), diphenyltin (IV) di 4 chlorobenzoate (DPDC) (3), diphenyltin(IV) di-4-hydroxybenzoate (DPDH) (4), and diphenyltin(IV) di-4-nitrobenzoate (DPDN) (5), and they were prepared by reacting diphenyltin(IV) oxide (DPO) (1) with benzoic acid derivatives of 4-aminobenzoic acid (4-HABz), 4-chlorobenzoic acid (4-HCBz), 4-hydroxybenzoic acid (4-HHBz) and 4-nitrobenzoic acid (4-HNBz), respectively. The compounds were well characterized by H-1, C-13 NMR, IR, UV spectroscopies, and their pieces were defined using microanalytical data. The disinfectant test was carried out on two bacteria, Gram-negative Salmonella sp., and Gram-positive Staphylococus aureus. The result showed that all of the compounds were active as a disinfectant (disinfecting agent) with a minimum inhibitory concentration of 5 x 10(-4) M. Compound 5 was found to be most active compared to others which exhibited the ability to reduce the concentration of the S. aureus bacteria within 5 min.
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关键词
Chemistry and its applications, diphenyltin(IV) dibenzoate derivative, disinfecting activity, S, aureus, Salmonella sp, VCCA-2021
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