Optimized Methodology for Reference Region and Image-Derived Input Function Kinetic Modeling in Preclinical PET

Jason Bini,Christine R. Lattin,Takuya Toyonaga,Sjoerd J. Finnema,Richard E. Carson

IEEE Transactions on Radiation and Plasma Medical Sciences（2022）

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摘要

Positron emission tomography (PET) imaging of small animals is often used for assessing biodistribution of a novel radioligand and pharmacology in small animal models of disease. PET acquisition and processing settings may affect reference region or image-derived input function (IDIF) kinetic modeling estimates. We examined four different factors in comparing quantitative results: 1) effect of rec...

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关键词

Kinetic theory,Image reconstruction,Attenuation,Positron emission tomography,Mice,Data models,Blood

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