CORRELATIONS BETWEEN THE EXPRESSION OF CYFRA21-1, DCR3, AND CARCINOEMBRYONIC ANTIGEN AND THE SEVERITY OF IDIOPATHIC INTERSTITIAL PNEUMONIA

Objective: To analyze the correlations between the expression of cytokeratin 19 (CYFRA21-1), decoy receptor 3 (DcR3), and carcinoembryonic antigen (CEA) and the severity of idiopathic interstitial pneumonia (IIP). Methods: From September 2018 to August 2019, 34 patients with IIP, 34 patients with nonspecific interstitial pneumonia, and 34 healthy controls were selected as the IIP group, while 34 patients with nonspecific interstitial pneumonia were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect changes in the serum CYFRA21-1, DcR3, and CEA levels. Forced vital capacity (FVC), forced expiratory volume (FEV1), FEV1/FVC, and carbon monoxide diffusion capacity (DLCO) were detected by a pulmonary function instrument; chest high-resolution CT (HRCT) score was used for each group. Spearman correlation analysis was used to analyze the correlations between CYFRA21-1, DcR3, and CEA levels and pulmonary function and HRCT score. Results: Compared with the normal control group, the serum CYFRA21-1, DcR3, and CEA levels in the IIP and NSIP groups were significantly increased (P<0.05), and the serum CYFRA21-1, DcR3, and CEA levels in the IIP group were significantly higher than those in the NSIP group (P<0.05). Compared with the normal control group, the lung function indexes of the IIP and NSIP groups were significantly decreased (P<0.05), and the IIP group was significantly lower than the NSIP group; the difference was statistically significant (P<0.05). The changes in serum CYFRA21-1, DcR3, and CEA levels were significantly positively correlated with HRCT scores (P<0.05), while serum CYFRA21-1, DcR3, and CEA levels were negatively correlated with lung function indexes (P<0.05). Conclusion: The serum CYFRA21-1, DcR3, and CEA levels in patients with IIP are higher, and have significant correlation with the severity of IIP in those patients. Joint detection is conducive to timely assessment and monitoring of disease development in IIP patients, and provides a new method for the treatment of IIP patients.