Impact of belatacept and tacrolimus on cytomegalovirus viral load control and relapse in moderate and high-risk cytomegalovirus serostatus kidney transplant recipients.

Wairimu Magua,Aileen C Johnson,Geeta M Karadkhele,Idelberto R Badell,Payaswini Vasanth,Aneesh K Mehta,Kirk A Easley,Kenneth A Newell, Joseph B Rickert,Christian P Larsen

AMERICAN JOURNAL OF TRANSPLANTATION（2022）

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摘要

High-risk belatacept-treated recipients showed defects in sustaining viral control relative to tacrolimus-treated recipients. Avoidance of initial use belatacept in high-risk recipients or development of modified management protocols should be considered.

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CMV bidirectional viral load state transitions,CMV control,CMV high-risk,CMV management strategies,CMV moderate-risk,CMV relapse,CMV serostatus risk,CMV viral infection and infectious agents,CMV viral load dynamics,CMV viral load volatility,Markov multistate,belatacept,clinical research/practice,cytomegalovirus,immunosuppression/immune modulation,immunosuppressive regimens-maintenance,infectious disease,kidney (allograft) function/disfunction,kidney transplant,length of stay in viral load state,tacrolimus,viral load trajectory,viremia

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