Short Tandem Repeat Contractions during In Vitro DNA Synthesis by Repeat-binding Molecules

Masaki Hagihara,Chikara Dohno,Kaoru Saito, Kazuhiro Sugimoto, Yuta Hishinuma, Yuri Sohma,Tomonori Shibata,Kazuhiko Nakatani

CHEMISTRY LETTERS（2021）

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摘要

We demonstrate here that DNA-binding small molecules stabilize hairpin structures formed in short tandem repeat sequences, leading to efficient contractions of repeats during in vitro DNA synthesis. Repeat contraction by synthetic small molecules shows a repeat-number and sequence selective manner.

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关键词

Short tandem repeats, Mismatch binding ligands, In vitro DNA synthesis

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