A Case of severe mosquito bite allergy complicated by fatal hemophagocytic lymphohistiocytosis
PEDIATRIC DERMATOLOGY(2022)
摘要
Severe mosquito bite allergy (SMBA) is characterized by necrotic skin lesions and systemic symptoms. Chronic active Epstein-Barr virus (EBV) infection, when superimposed with SMBA, is a key driver for catastrophic clinical consequences, such as uncontrolled lymphoproliferation. This interplay is of clinical significance due to its association with hemophagocytic lymphohistiocytosis (HLH) and/or EBV-driven malignancies. Here, we report a case of SMBA that developed in a 14-year-old Hispanic boy that led to fatal secondary HLH.
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关键词
chronic active EBV infection, EBV, EBV-associated T-, NK-cell lymphoproliferative disease, hemophagocytic lymphohistiocytosis, mosquito bite
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