Nicotinamide mononucleotide (NMN) and NMN-rich product supplementation alleviate p-chlorophenylalanine-induced sleep disorders

Nicotinamide mononucleotide (NMN) has been popularly applied owing to its various beneficial effects. In this study, effects of dietary NMN and NMN-rich product (NMNP) intervention on p-chlorophenylalanine (PCPA)-induced sleep disorders were comparatively investigated. The results showed that NMN and NMNP administration exhibited potent sedative effects on PCPA-induced mice through modulating the oxidative stress, SIRT1 pathway, 5-HTergic, GABAergic and immune systems. Various chemical constituents in NMNP might produce synergistic or additive effects.