The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

The copper oxide nanoparticles (CuO NPs) were synthesized by a simple method and then coated with the bovine serum albumin (BSA) to form CuO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug was loaded to the CuO@BSA NPs. The characterization of nanoparticles was carried out by Fourier-transport infrared (FT-IR), ultraviolet-visible (UV-vis), transmission electron microscopy (TEM), and atomic force microscopy (AFM) analysis. It was found that the synthesized CuO@BSA-CUR nanoparticles were spherical with a particle size of 20–30 nm. Also, the result of drug release in the biological environment showed that maximum drug release for this nanocarrier in pH of 7.4 was measured 72% after 48 h. The cytotoxicity of CuO@BSA-CUR against the MDA-MB-231 breast cancer cell line was studied by MTT assay test. The results indicated that CuO@BSA-CUR nanoparticles have a remarkable anticancer effect on breast cancer cell line.