Beneficial effects of nano-phytosome of Quercetin on inflammatory parameters in mouse model of multiple sclerosis

This study evaluated the beneficial effects of quercetin nano-phytosome on inflammatory parameters in multiple sclerosis. The animals were divided into five groups, including Control, 150 Quercetin, 300 Quercetin, 150 and 300 nano-phytosome of Quercetin. At the end of the study, serum levels of Granulocytemacrophage colony stimulator (GMCSF), interleukin 1 beta (IL1 beta), interleukin 2 (IL2), interleukin 6 (IL6), interleukin 10 (IL10), interleukin 17 (IL17), Interleukin gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) were determined. The results showed that administration of Quercetin and its nano-phytsome significantly decreased the levels of IL-1 beta, IL-2, IL-6, IL-17, IFN-gamma, TNF-alpha and GM-CSF and increased IL-10 in comparison to the control group. The treated animals with nano-phytsome significantly decreased IL-2, IL-1 beta, IL-17, IL-6, IFN-gamma, TNF-alpha and GM-CSF and increased IL-10 compared with Quercetin group. Quercetin nanophytosomes can be used to effectively improve inflammation. We recommend using quercetin nanophytosomes to reduce inflammation in patients with multiple sclerosis.