Hybrid Flow-Batch Model for the Efficient Synthesis of 2‑(Dimethylamino)-6-methylpyridin-4-ol

A practical and scalable method for the synthesis of 2-(dimethylamino)-6-methylpyridin-4-ol is described. Despite its structural simplicity, the synthesis and isolation of this molecule in useful yields has proven to be challenging. A hybrid-flow (flow–batch–flow) mode approach was designed to circumvent issues associated with the safety and technical limitations of some of the steps in the process. The synthesis was successfully implemented to generate multigram quantities of a key intermediate for a drug candidate.