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Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRASG12C Inhibitors

Grigorios Nikitidis,Anna-Carin C. Carlsson,Staffan Karlsson,Andrew D. Campbell,Calum Cook,Kuangchu Dai,Hans Emtenas,Anna C. Jonson,Hanna Leek,Marcus Malmgren,Stefan Moravcik,Subhash Pithani,Matthew R. Tatton,Hucheng Zhao,Kristina Ohlen

Organic Process Research & Development（2021）

引用 11|浏览23
关键词
Suzuki coupling,atropisomers,nitration,acryloyl amide,supercritical fluid chromatography,oncology
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