A NEW NATURAL BUTENOLIDE, (5R)-3-TETRADECYL-5-METHYL-2(5H)-FURANONE, FROM OCTOCORAL CLADIELLA CONIFERA

Jhao-Syuan Zeng,Shun-Hua Chen,Yi-Hao Lo,Nan-Fu Chen,Zhi-Hong Wen,Jih-Jung Chen,Chia-Ching Liaw,Ping-Jyun Sung

HETEROCYCLES（2022）

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摘要

A chemical examination of Cladiella conifera, octocoral collected in the waters of Taiwan, resulted in isolation of a new natural butenolide, (5R)-3-tetradecyl-5-methyl-2(5H)-furanone (1). The structure, including the absolute configuration, of 1 was established by spectroscopic analysis and 1 was found to inhibit the generation of COX-2 from RAW 264.7 stimulated by LPS.

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octocoral cladiella conifera,new natural butenolide

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