Design, synthesis and biochemical evaluation of novel 2-amino-3-(7-methoxybenzo[d][1,3]dioxol-5-yl)propanoic acid using Horseradish peroxidase (HRP) activity, cellular ROS inhibition and molecular docking study

•Design, synthesis and biochemical evaluation of novel amino acid with benzodioxole core (9) is presented.•Crystal structure of the precursor 16 is described and analyzed using Hirshfeld surface.•Compound 9 showed good antiradical activity confirmed by docking study with HRP.•Tested compounds moderately inhibit ROS produced by PMA-activated HL60 cells.•Except myristicin aldehyde, all tested compounds are not cytotoxic for HL60 cells.