Alternative synthetic approaches for nucleotides and derivatives
Phosphorus, Sulfur, and Silicon and the Related Elements(2022)
摘要
We have focused our attention on alternative synthetic approaches for nucleotides and dinucleotides, that simplifies purification and/or improves sustainability. On one hand, we developed a liquid-phase synthesis using a benzene-centred tripodal support to prepare adenine nucleoside phosphoesters and methylenebisphosphonate derivatives. On the other hand, we used mechanochemistry, a technique that enables solid/solid reactions through mechanical grinding under solventless or solvent-free conditions, to get access to dinucleotides.
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关键词
Organophosphorus chemistry,nucleotides,dinucleotides,supported synthesis,mechanochemistry
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