Antioxidant and neuroprotective activities of selected 2-pyridones: In vitro and in silico study

Tanja Lunic,Jelena Ladarevic,Marija Mandic,Vanja Verusevski,Biljana Bozic Nedeljkovic,Dusan Mijin,Bojan Bozic

Journal of Molecular Structure（2022）

引用 6|浏览18

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摘要

•Seven selected 2-pyridones exhibited excellent antioxidant activities.•Significant anti-neuroinflammatory activity was observed in vitro using BV2 cells.•Significant neuroprotective activity was detected in vitro using SH-SY5Y cells.•Docking study revealed interactions with iNOS and TLR4 signaling pathway proteins.

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关键词

Pyridone derivatives,Antioxidants,Neuroprotection,Neuroinflammation,Docking study

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