Genistein: A novel inhibitor of IL-6/IL-6R interface of the Interleukin-6–mediated STAT3 dependent pathway of carcinogenesis

Saurabh Sharma,Lakshay Malhotra,Prakarsh Yadav,Vandana Mishra,Radhey Shyam Sharma,Ethayathulla Abdul Samath

Journal of Molecular Structure（2022）

引用 9|浏览4

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摘要

•Overexpression of STAT3 increases metastases in breast cancer.•IL-6/IL-6 receptor/GP130 complex mediates the STAT3 pathway.•Genistein prevent IL-6/IL-6 receptor complex formation to inhibits the STAT3 pathway.•Genistein inhibit cell proliferation of MDA-MB 453 metastatic breast cancer cell line.

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关键词

Breast cancer,IL-6/STAT3 signaling pathway,Molecular docking,Molecular dynamics simulation,Cytotoxicity assay

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