ANTIBACTERIAL AND MODULATORY ACTIVITY OF A-PINENO ASSOCIATED WITH THE LED DEVICE

The abuse of drugs and their indiscriminate sale are one of the main factors for bacterial resistance, which is a serious health problem. Essential oils are a source of bioactive compounds that may have antimicrobial properties. In this context, alpha-pinene stands out, a monoterpene that can be extracted from essential oils of plants and has medicinal action. Thus, the present work aims to evaluate the antimicrobial and modulating activity of alpha-pinene when associated with the Light Emitting Diodes (LED) apparatus against multiresistant bacterial strains. For this purpose, the gaseous contact technique and modulation with antibiotics and blue LED light were used to determine the antimicrobial activity. The minimum inhibitory concentration (MIC) of the alpha-pinene was >= 1024 mu g/mL. Possible synergism occurred between alpha-pinene associated with antibiotics and LED light of the class of Quinolones (Norfloxacin, Ciprofloxacin), Aminoglycosides (Gentamicin, Am ikacin) and Beta Lactamic (Penicillin G and Oxacillin) that showed inhibitory potential against multidrug-resistant strains of Staphylococcus aureus and Escherichia coli. The results indicate that the alpha-pinene has a synergistic action when associated with conventional antibiotics, such as amikacin, which satisfactorily inhibited E. coli and oxacillin, which inhibited S. aureus. In this sense, alpha-pinene may be a compound with beneficial effects for the treatment of bacterial infections related to resistant strains.