Role of structural properties of bioactive peptides in their stability during simulated gastrointestinal digestion: A systematic review

•Bioactive peptides can be stable or unstable to gastrointestinal proteases.•Structural biostability of food peptides depends on their structural properties.•Chain length, size, hydrophobicity and cationic charge are major biostability determinants.•Branched-chain aliphatic N-terminal residues, histidine and proline are also important.•Findings provide important guidelines for selecting and designing biostable peptides.