THE EFFECT OF USE OF DIFFERENT DOSES OF URSODEOXYCOLIC ACID ON GALLSTONE FORMATION AFTER SLEEVE GASTRECTOMY

Objective: To evaluate the effects of using different doses of ursodeoxycholic acid (UDCA) for six months in prevention of gallstones after Laparoscopic Sleeve Gastrectomy (LSG) on the formation of gallstones in the 6th and 12th months. Materials and Methods: The data of patients who underwent LSG for morbid obesity were analyzed. Three groups of 20 people were formed. These were the control group, Group I who were treated with UCDA 500 mg/day for six months after LSG, and Group II who were treated with UCDA 1000 mg/day for 6 months after LSG. Demographic characteristics, co-morbid diseases, cholesterol and triglyceride differences before and after surgery, excess weight loss (EWL%), total weight loss (TWL%), body mass index (BMI), and abdominal ultrasound (US) data for the occurrence of cholelithiasis (CL) preoperatively and at six and 12 months after surgery were collected. Results: The results of tests taken on these patients in the sixth month revealed that the stone detection rate in the US results of the control group was significantly higher than that in Group II (p=0.001; p<0.01). There was no statistically significant difference between the control group and Group I (p=0.149), and between Group I and Group II (p=0.066). The results of tests taken in the 12th month showed that the stone detection rate in the US results of the control group was significantly higher than Group I and Group II (p=0.010; p<0.05). There was no statistically significant difference between Group I and Group II. Conclusion: As a result of this study, we recommend that pa-tients be given 1000 mg/day UDCA after LSG.