Copper-Catalyzed Cross-Dehydrogenative Phosphorylation of 2-Amino-1,4-naphthoquinones with H-Phosphonates

As a simple and efficient system, Cu(OAc)(2) . H2O and K2S2O8 can activate H-phosphonates to produce the corresponding dialkyl phosphoryl radicals. The obtained dialkyl phosphoryl radicals react smoothly with 2-amino-1,4-naphthoquinones, affording accurate preparation of various phosphoryl-functionalized 2-amino-1,4-naphthoquinones. The developed copper-catalyzed cross-dehydrogenative phosphorylation features broad substrate scope, easily available reagents, high atom economy and operational simplicity, which enables a practical avenue for C-P bond formation.