In-silico evaluation of 'Mirror Repeats' In HIV Genome

The repetitive sequences played an important role in the characterization of both prokaryotic & eukaryotic organisms. Various different patterns of repetitive sequences have also been identified in organisms. Among all the repeat sequences. Mirror Repeats (MR's) play an important role in various types of neurological disorders. These MR's have also been reported for structure determination of genomes, triplex DNA formation & various other genome functions. We have followed a distinguished method referred to as FPCB (FASTA PARALLEL COMPLEMENT BLAST) for the identification of MR's. The above said method used to identify MR's in both types of HIV viruses (HIV-I & HIV 2). Present investigation reported that MR's are frequently distributed in all the regions of the genomes of both types. As a result, 232 & 248 total numbers of MR's identified in both the HIV-I & HIV-2 genome respectively. In addition, it was also revealed that the majority of the identified sequences are imperfect. The maximum length of MR's in HIV- I is of 47 nucleotides (NTD's), however in case of HIV-2, it is of 49 nucleotides (NTD's). Present investigation will be helpful for further development of a link between mirror repeats and host genome, which will be a new trend to block the viral integration as well as pathogenicity.