Micro-RNA-124-5p promotes insulin producing cell differentiation through regulating transcriptional factor NKX6.1

Xianjun Zhang, Shunzi Shao,Xijiang Zhao, Meng Zhang,Jingbo Wang

Biochemistry and Biophysics Reports（2022）

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摘要

•miR-124-5p is upregulated during the IPCs differentiation.•Inhibition of miR-124-5p enhances Nkx6.1 expresssion.•miR-124-5p promotes the specification of IPCs from hESCs.

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关键词

miR-124-5p,Insulin-producing cells,NKX6.1,Human embryonic stem cells,Diabetes

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