The importance of targeting signalling mechanisms of the SLC39A family of zinc transporters to inhibit endocrine resistant breast cancer.

Exploration of targeted anti-tumor therapy(2022)

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摘要
TAMR cells displayed increased activity of both ZIP7 and ZIP6 transporters compared to anti-hormone responsive cells, suggesting their potential as novel therapeutic targets following development of resistant disease.
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关键词
SLC39A10,SLC39A6,SLC39A7,STAT3,ZIP6,ZIP7,Zinc transport,tamoxifen resistance
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