Advances in Nanomedicine Design: Multidisciplinary Strategies for Unmet Medical Needs br

Globally, a rising burden of complex diseases takesa heavy toll on human lives and poses substantial clinical andeconomic challenges. This review covers nanomedicine andnanotechnology-enabled advanced drug delivery systems (DDS)designed to address various unmet medical needs. Key nano-medicine and DDSs, currently employed in the clinic to tacklesome of these diseases, are discussed focusing on their versatility indiagnostics, anticancer therapy, and diabetes management. First-hand experiences from our own laboratory and the work of othersare presented to provide insights into strategies to design andoptimize nanomedicine- and nanotechnology-enabled DDS forenhancing therapeutic outcomes. Computational analysis is alsobriefly reviewed as a technology for rational design of controlledrelease DDS. Further explorations of DDS have illuminated the interplay of physiological barriers and their impact on DDS. It isdemonstrated how such delivery systems can overcome these barriers for enhanced therapeutic efficacy and how new perspectives ofnext-generation DDS can be applied clinically.