Novel linezolid-based oxazolidinones as potent anticandidiasis and antitubercular agents

•Novel series of linezolid-based oxazolidinones were designed and synthesized by selected modifications.•Potent anticandidiasis activity exhibited by oxazolidinone (2, 3a) against 14 strains of C.albicans.•Demonstration of mechanism of action by the inhibition of ergosterol biosynthesis.•Excellent antitubercular activity displayed by oxazolidinone (2, 3a), comparable to linezolid.•Computational studies revealed the superior or comparable binding affinity of the oxazolidinone towards the biological receptors than controls.