Construction and validation of a novel apoptosis-associated prognostic signature related to osteosarcoma metastasis and immune infiltration

•Osteosarcoma is one of the most aggressive diseases which often develops metastasis.•Apoptosis relates to the recurrence and metastasis of osteosarcoma and the related signature could predict the prognosis of patients.•A novel apoptosis-associated prognosis signature related to osteosarcoma metastasis and immune infiltration has been developed.•The signature could help to predict the prognosis of osteosarcoma patients and serve as the potential targets for anti-cancer treatment.