The influence of green tea extract on nintedanib’s bioavailability in patients with pulmonary fibrosis

G D Marijn Veerman, Sanne C van der Werff,Stijn L W Koolen,Jelle R Miedema,Esther Oomen-de Hoop,Sophie C van der Mark,Prewesh P Chandoesing,Peter de Bruijn,Marlies S Wijsenbeek,Ron H J Mathijssen

Biomedicine & Pharmacotherapy（2022）

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摘要

Nintedanib is an oral small-molecule kinase inhibitor and first-line treatment for idiopathic pulmonary fibrosis. Nintedanib is a substrate of the drug efflux transporter ABCB1. Green tea flavonoids --especially epigallocatechin gallate (EGCG)-- are potent ABCB1 modulators. We investigated if concomitant administration of green tea extract (GTE) could result in a clinically relevant herb-drug interaction.

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关键词

Nintedanib,Pharmacokinetics,Green tea,Flavonoids,Interaction,Pulmonary fibrosis

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