FLASH with carbon ions: Tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model

Walter Tinganelli,Uli Weber, Anggraeini Puspitasari,Palma Simoniello,Amir Abdollahi, Julius Oppermann,Christoph Schuy,Felix Horst,Alexander Helm,Claudia Fournier,Marco Durante

Radiotherapy and Oncology（2022）

引用 29|浏览7

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摘要

•FLASH radiotherapy with carbon ions was demonstrated for the first time in vivo.•FLASH (100 Gy/s) reduced normal tissue toxicity and tumor growth.•FLASH irradiation reduces the number of lung metastases.

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关键词

FLASH effect,Carbon ions,Heavy ion therapy,Mouse osteosarcoma,Metastasis suppression

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