Electrostatics Drive the Molecular Chaperone BiP to Preferentially Bind Oligomerized States of a Client Protein

Erin E Deans,Judy L M Kotler,Wei-Shao Wei,Timothy O Street

Journal of Molecular Biology（2022）

引用 2|浏览4

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摘要

•BiP binds proIGF2 client protein oligomers with higher affinity than monomers.•Electrostatics boost the affinity of BiP to proIGF2 oligomers.•Electrostatic steering accelerates BiP binding to proIGF2 oligomers.•Electrostatics provide a potential explanation for other cases in which chaperones have been found to bind client oligomers with high affinity.

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关键词

BiP chaperone,client protein oligomer,electrostatic steering,IGF2,molecular recognition

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