Inadequacy of Evolutionary Profiles Vis-a-vis Single Sequences in Predicting Transient DNA-Binding Sites in Proteins

Ajay Arya,Dana Mary Varghese,Ajay Kumar Verma,Shandar Ahmad

Journal of Molecular Biology（2022）

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摘要

•A database of closely related DNA-binding protein pairs with binding site mapping is developed.•Binding sites and amino acid substitutions in pairs are classified as conserved or transient.•Transient residues and their DNA-binding are analyzed structurally and sequence-based predictability.•Machine learning with single sequences clearly outperform PSSM in predicting transient DNA-binding residues.

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关键词

Protein-DNA interactions,DNA-binding sites,Specificity determining positions,Transient and conserved binding sites

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