Chemokine receptor 4 expression on blood T lymphocytes predicts severity of major depressive disorder

Jana Freff,Eva C Beins,Lisa Bröker,Kathrin Schwarte,Rafael Leite Dantas,Carlo Maj,Volker Arolt,Udo Dannlowski,Markus M Nöthen,Bernhard T Baune,Andreas J Forstner,Judith Alferink

Journal of Affective Disorders（2022）

引用 3|浏览16

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摘要

•CCR4 expression on CD4+ T cells is decreased in MDD.•Serum CCL17 and CCL22 levels are increased in MDD.•Severity of MDD is associated with CCR4 expression levels on CD4+ T cells.•CCR4 and cross-disorder and chronotype PRS predict severity of MDD.

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关键词

T cells,Major depression,Inflammation,Immune system,Chemokines,Polygenic risk score

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