Pulmonary haemorrhage as the earliest sign of severe leptospirosis in hamster model challenged with Leptospira interrogans strain HP358.

Noraini Philip,Sivan Padma Priya, Ahmad Hussein Jumah Badawi, Mohd Hafidz Mohd Izhar,Norhafizah Mohtarrudin, Tengku Azmi Tengku Ibrahim,Zamberi Sekawi,Vasantha Kumari Neela

PLoS neglected tropical diseases（2022）

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摘要

This study deciphered haemorrhage as the earliest manifestation of severe leptospirosis and high levels of IL-1β, CXCL10/IP-10, CCL3/MIP-α, neutrophils and low levels of lymphocytes and platelets serve as a cumulative panel of biomarkers in severe leptospirosis.

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