In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations

•GNA11 mutations are associated with increased risk of death in uveal melanoma.•GNA11 mutated uveal melanoma shows high risk cytogenetics and gene expression.•GNAQ but not GNA11 protein physically interacts with the demethylating enzyme TET2.•GNAQ and GNA11 mutated uveal melanoma shows different DNA-methylation patterns.