Prussian blue nanoparticles: an advanced platform for multimodal imaging

Iron-oxide nanoparticles have long been studied for their superparamagnetic properties. These T2-MRI contrast agents (CAs) cause a hypointense change of the MR image, making it difficult to visually detect and diagnose most small tumor detail. Currently, Gd and Mn-containing substances are commercially available as contrast agents; however, they are known to have strong toxic effects. Recently we developed Prussian blue nanoparticles (PBNPs) with a biocompatible surface by using a modified and improved one-step synthesis method.