Toll-Like Receptor Signaling in the Pathogenesis of Chronic Dacryocystitis: Implication of c-FOS Transcription Factor and its Downstream Effector Chemokine Genes CCL2, CCL4, CXCL3, CXCR4 with a Shift of the M1/M2 Macrophage Phenotype.

Noha Ahmed Edris,Basma Emad Aboulhoda,Shimaa Saad El-Din,Amina Mahmoud Fouad,Emad Albadawi,Laila Ahmed Rashed,Kareem Bakr Elessawy

Combinatorial chemistry & high throughput screening（2023）

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摘要

It is essential to fine-tune TLR activation through emerging therapeutic approaches. Targeting TLR signaling at the level of receptors or downstream adaptor molecules represents a new challenge for treating chronic dacryocystitis.

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关键词

Toll-Like receptors,chemokines,chronic dacryocystitis,epipjora,macrophage polarization,pro-inflammatory cytokines

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