mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data.

Roberta Celli,Pasquale Striano,Rita Citraro,Luisa Di Menna,Milena Cannella,Tiziana Imbriglio,Mahmoud Koko, Euro Epinomics-Cogie Consortium,Giovambattista De Sarro,James A Monn,Giuseppe Battaglia,Gilles Van Luijtelaar,Ferdinando Nicoletti,Emilio Russo,Antonio Leo

Current neuropharmacology（2023）

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摘要

We suggest that mGlu3 receptors modulate the activity of the cortico-thalamo-cortical circuit underlying SWDs and that selective mGlu3 receptor agonists are promising candidate drugs for absence epilepsy treatment.

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关键词

Absence epilepsy,EEG,GABA,cortico-thalamo-cortical network,glutamate,human genetics,mGlu3 receptors

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