The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer

•The structure of glycoprotein Gc, responsible for membrane fusion, is revealed, but many more mysteries remain.•Why do only antibodies against Gc have neutralizing effect, but not the one against Gn?•Why can NAbs against Gc only be protective in the animals in preventive settings, but not in the therapeutic administration?