Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation.

Yuxuan Guo,Yangpo Cao,Blake D Jardin,Xiaoran Zhang,Pingzhu Zhou,Silvia Guatimosim,Junsen Lin,Zhan Chen, Yueyang Zhang,Neil Mazumdar,Fujian Lu,Qing Ma,Yao-Wei Lu,Mingming Zhao,Da-Zhi Wang,Erdan Dong,William T Pu

Cardiovascular research（2023）

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摘要

RYR2-regulated ER homeostasis is essential for cardiomyocyte maturation. Severe ER stress perturbs cardiomyocyte maturation primarily through ATF4 activation. The major downstream effector genes of ATF4 are related to protein biosynthesis.

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关键词

Cardiomyocyte maturation,ER stress,Ryanodine receptor 2

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