Design of a Potent, Selective and Brain Penetrant Inhibitor of Wnt-deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
Nicky J. Willis,William Mahy,James Sipthorp,Yuguang Zhao,Hannah L. Woodward,Benjamin N. Atkinson,Elliott D. Bayle,Fredrik Svensson,Sarah Frew,Fiona Jeganathan,Amy Monaghan,Stefano Benvegnu,Sarah Jolly,Luca Vecchia,Reinis R. Ruza,Svend Kjaer,Steven Howell,Ambrosius P. Snijders,Magda Bictash,Patricia C. Salinas,Jean-Paul Vincent,E. Yvonne Jones,Paul Whiting,Paul Fish Journal of Medicinal Chemistry（2022）
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Drug Target Identification
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