Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity

Xi Chen,Hui Zhang,Wu Zeng, Nick Wang,Hang Hong Lo,Chi Kio Ip,Li Jun Yang,W.L. Wendy Hsiao,Wai Man Sin,Chenglai Xia,Betty Yuen Kwan Law,Vincent Kam Wai Wong

Journal of Advanced Research（2022）

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摘要

•FIR treatment improved adjuvant arthritis in rats.•FIR exposure inhibited the inflammatory genes expression of synovial tissues in AIA rats.•FIR exposure down-regulated inflammatory genes expression mainly through transcription factors AP-1, CEBPα, CEBPβ, c-Fos, GR, HNF-3β, USF-1, and USF-2.•FIR irradiation may exhibit anti-arthritic effects through inactivation of the MAPK, PI3K-Akt, and NF-κB signaling pathways.

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关键词

Far infrared irradiation (FIR),Adjuvant-induced arthritis (AIA),Inflammatory response,Autoimmunity,Transcription factors

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