Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia

Asha Kishore,Praveen James,Parvathy Rajeswari,Gangadhara Sarma,Syam Krishnan,Sabine Meunier,Traian Popa

Parkinsonism & Related Disorders（2022）

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摘要

•Depotentiation of heterosynaptic M1 plasticity (PAS) is intact in dyskinetic PD.•Lack of depotentiation in dyskinetic PD applies only to homosynaptic M1 plasticity.•The anti-dyskinetic effect of cerebellar inhibitory stimulation could occur by depotentiation in M1.

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关键词

Dyskinesia,Parkinson's disease,Depotentiation,Long-term potentiation,Cerebellum,Levodopa

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